Inspirex® Lung
Bioengineered human lung graft for clinical transplantation
PRESSING NEED
More lung grafts for transplant
The wait for a lung transplant is a battle against time. Many patients spend years on the transplant waiting list, only to face rejection, complications, or even death while waiting for an organ to become available. Inspirex® Lung offers a lifeline to those who have exhausted all other options.
MEDICAL BREAKTHROUGH
Inspirex® Lung
Generated using our groundbreaking xenogeneic cross-circulation platform, Inspirex® Lung is a bioengineered human lung graft with whole organ functionality and anatomical compatibility for clinical transplantation.
IMPACT
Transforming the future of lung transplant
Lung transplants have only increased incrementally over the past 20 years. The availability of Inspirex® Lung holds potential to enable significantly more lung transplants and eliminate lung transplant waitlist mortality in the U.S.
- Organ Procurement & Transplant Network/Scientific Registry of Transplant Recipients. Annual Data Report, 2024.
REFERENCES
- O’Neill JD, Guenthart BA, Kim J, Chicotka S, Queen D, Fung K, et al. Cross-circulation for extracorporeal support and recovery of the lung. Nat Biomed Eng. 2017; 1: 1-15.
- Guenthart BA, O’Neill JD, Kim J, Queen D, Chicotka S, Fung K, et al. Regeneration of severely damaged lungs using an interventional cross-circulation platform. Nat Commun. 2019;10: 1-16.
- Hozain AE, Tipograf Y, Pinezich MR, Cunningham KM, Donocoff R, Queen D, et al. Multi-day maintenance of extracorporeal lungs using cross-circulation with conscious swine. J Thorac Cardiovasc Surg. 2019; 159: 1640-1653.
- Hozain AE, O’Neill JD, Pinezich MR, Tipograf Y, Donocoff R, Cunningham KM, et al. Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs. Nat Med. 2020; 26:
1102-1113. - O’Neill JD, Guenthart BA, Hozain AE, Bacchetta M. Xenogeneic support for the recovery of human donor organs. J Thorac Cardiovasc Surg. 2022; 163: 1563-70.
- Wu WK, Guenthart BA, O’Neill JD, Hozain AE, Tipograf Y, Ukita R, et al. Technique for xenogeneic cross-circulation to support human donor lungs ex vivo. J Heart Lung Transplant. 2023; 42(3):
335-344. - Wu WK, Stier MT, Stokes JW, Ukita R, Patel YJ, Cortelli M, et al. Immune characterization of a xenogeneic human lung cross-circulation support system. Sci Adv. 2023; 9(13): 1-13.