Inspirex® Lung
Ex vivo organ support system for rehabilitating human donor lungs for clinical transplantation
Pioneering donor organ repair & regeneration
Inspirex® enables repair and transplantation of human donor lungs not currently being utilized for transplant, directly benefitting patients in need of a life-saving organ transplant.
Groundbreaking approach to rehabilitate human donor
lungs for transplant
Inspirex® supports and recovers human donor lungs ex vivo by providing durable multi-system physiologic regulation via a xenosupport pig. This robust regenerative setting significantly improves cellular regeneration and functional recovery and radically extends the time for organ evaluation and therapeutic intervention.
Improves organ function to meet transplant criteria:
Integrated
Normothermic
Systemic
Physiology for
Interventional
Rehabilitation and
Evaluation using
Xenosupport
REFERENCES
- O’Neill JD, Guenthart BA, Kim J, Chicotka S, Queen D, Fung K, et al. Cross-circulation for extracorporeal support and recovery of the lung. Nat Biomed Eng. 2017; 1: 1-15.
- Guenthart BA, O’Neill JD, Kim J, Queen D, Chicotka S, Fung K, et al. Regeneration of severely damaged lungs using an interventional cross-circulation platform. Nat Commun. 2019;10: 1-16.
- Hozain AE, Tipograf Y, Pinezich MR, Cunningham KM, Donocoff R, Queen D, et al. Multi-day maintenance of extracorporeal lungs using cross-circulation with conscious swine. J Thorac Cardiovasc Surg. 2019; 159: 1640-1653.
- Hozain AE, O’Neill JD, Pinezich MR, Tipograf Y, Donocoff R, Cunningham KM, et al. Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs. Nat Med. 2020; 26: 1102-1113.
- O’Neill JD, Guenthart BA, Hozain AE, Bacchetta M. Xenogeneic support for the recovery of human donor organs. J Thorac Cardiovasc Surg. 2022; 163: 1563-70.
- Wu WK, Guenthart BA, O’Neill JD, Hozain AE, Tipograf Y, Ukita R, et al. Technique for xenogeneic cross-circulation to support human donor lungs ex vivo. J Heart Lung Transplant. 2023; 42(3): 335-344.
- Wu WK, Stier MT, Stokes JW, Ukita R, Patel YJ, Cortelli M, et al. Immune characterization of a xenogeneic human lung cross-circulation support system. Sci Adv. 2023; 9(13): 1-13.
- Pinezich MR, O’Neill JD, Guenthart BA, Kim J, Vila OF, Ma SP, Hozain AE, et al. Theranostic methodology for ex vivo donor lung rehabilitation.