Inspirex™ Lung
Ex vivo organ support system for rehabilitating human donor lungs for clinical transplantation
Pioneering donor lung regeneration
Inspirex™ Lung rehabilitates human donor lungs that are not currently utilized for transplantation to significantly increase the number of lungs available for patients in need of a life-saving transplant.
The donor lung shortage remains dire
People on the U.S. transplant waitlist in need of an organ
Additional patients who would benefit from a transplant
Donor lungs not currently utilized for transplantation
The majority of donated lungs are deemed unfit for transplant, often due to reversible conditions such as contusion, consolidation, and aspiration pneumonitis.
Rehabilitation of human donor lungs can significantly increase the number of lungs available for life-saving transplantation.
- Source: US Dept of Health & Human Services, Organ Procurement & Transplant Network (OPTN), National Data, 2021
Groundbreaking approach to rehabilitate donor lungs for transplant
Inspirex™ Lung rehabilitates human donor lungs ex vivo by providing durable multi-system physiologic regulation via normothermic cross-circulation with a xenosupport pig. This robust systemic support setting provides donor organs with homeostatic balance, anabolic synthesis, metabolic clearance, neurohormonal signaling, and other reparative mechanisms needed for lung regeneration and recovery of respiratory function.
Improved organ quality and function to meet transplant criteria:
158% average increase in gas exchange, * p < 0.05
45% average decrease in lung injury score, * p < 0.05
Publications
Science Advances
Immune characterization of a xenogeneic human lung cross-circulation support system
Nature Medicine
Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs
Journal of Heart and Lung Transplantation
Technique for xenogeneic cross-circulation to support human donor lungs ex vivo
Nature Communications
Regeneration of severely damaged lungs using an interventional cross-circulation platform
Journal of Thoracic and Cardiovascular Surgery
Multiday maintenance of extracorporeal lungs using cross-circulation with conscious swine
Nature Biomedical Engineering
Cross-circulation for extracorporeal support and recovery of the lung
Journal of Thoracic and Cardiovascular Surgery