Inspirex™ Liver

Ex vivo organ support system for rehabilitating human donor livers for clinical transplantation

Pioneering donor liver regeneration

Inspirex™ Liver rehabilitates human donor livers that are not currently utilized for transplantation to significantly increase the number of livers for patients in need of a life-saving transplant.

The donor liver shortage remains dire

5,500,000

People in the U.S. affected by liver cirrhosis

8,600

Liver transplants in the U.S. each year

5,200

Donor livers not currently utilized for transplantation

The number of patients in need of a donor liver far exceeds the number of livers available for transplant. Donor livers are often not used for transplant due to reversible conditions such as ischemic injury and steatosis.

Rehabilitation of human donor livers can significantly increase the number of livers available for life-saving transplantation.

Source: US Dept of Health & Human Services, Organ Procurement & Transplant Network (OPTN), National Data, 2021

Groundbreaking approach to rehabilitate donor livers for transplant

Inspirex™ Liver rehabilitates human donor livers ex vivo by providing durable multi-system physiologic regulation via normothermic cross-circulation with a xenosupport pig. This robust systemic support setting provides donor organs with homeostatic balance, anabolic synthesis, metabolic clearance, neurohormonal signaling, and other reparative mechanisms needed for liver regeneration and recovery of hepatic function.