Ex vivo organ support system for rehabilitating human donor livers for clinical transplantation
Pioneering donor liver regeneration
Inspirex™ Liver rehabilitates human donor livers that are not currently utilized for transplantation to significantly increase the number of livers for patients in need of a life-saving transplant.
The donor liver shortage remains dire
People in the U.S. affected by liver cirrhosis
Liver transplants in the U.S. each year
Donor livers not currently utilized for transplantation
The number of patients in need of a donor liver far exceeds the number of livers available for transplant. Donor livers are often not used for transplant due to reversible conditions such as ischemic injury and steatosis.
Rehabilitation of human donor livers can significantly increase the number of livers available for life-saving transplantation.
- Source: US Dept of Health & Human Services, Organ Procurement & Transplant Network (OPTN), National Data, 2021
Groundbreaking approach to rehabilitate donor livers for transplant
Inspirex™ Liver rehabilitates human donor livers ex vivo by providing durable multi-system physiologic regulation via normothermic cross-circulation with a xenosupport pig. This robust systemic support setting provides donor organs with homeostatic balance, anabolic synthesis, metabolic clearance, neurohormonal signaling, and other reparative mechanisms needed for liver regeneration and recovery of hepatic function.
Improved markers of organ quality and function:
Representative gross photography (top), thermography (middle), and ultrasonography (bottom) of livers across 36 hours of cross-circulation support.
Xenogeneic cross-circulation for physiologic support and recovery of ex vivo human livers
American Journal of Transplantation
Xenogeneic cross-circulation supports ex vivo human livers for 24 hours
American Society for Artificial Internal Organs (ASAIO) Journal