Inspirex® Liver
Ex vivo organ support platform for rehabilitating human donor livers for clinical transplantation
Pioneering donor organ repair & regeneration
Inspirex® Liver enables repair and transplantation of human donor livers not currently utilized for transplant, directly benefitting patients in need of a life-saving organ transplant.
BREAKTHROUGH BIOTECHNOLOGY
Groundbreaking approach to bioengineer human livergrafts for transplant
Inspirex® Liver supports and recovers human donor livers ex vivo by providing durable multi-system physiologic regulation via a xenosupport pig. This robust regenerative setting significantly improves cellular regeneration and functional recovery and radically extends the time for organ evaluation and therapeutic intervention.
TRANSFORMATIVE IMPACT
Inspirex® Liver holds potential to more than double the number of liver transplants
Liver transplants have only increased incrementally over the past 20 years. Inspirex® Liver holds potential to dramatically increase the number of livers for life-saving transplantation and eliminate liver transplant wait list mortality in the U.S.
- Organ Procurement & Transplant Network/Scientific Registry of Transplant Recipients. Annual Data Report, 2024.
REFERENCES
- Wu WK, Tumen A, Stokes JW, Ukita R, Hozain A, Pinezich M, O’Neill JD et al. Cross-circulation for extracorporeal liver support in a swine model. ASAIO. 2021; DOI: 10.1097/
MAT.0000000000001543. - Wu WK, Ukita R, Patel YJ, Cortelli M, Trinh VQ, Ziogas IA, et al. Xenogeneic cross-circulation for physiological support and recovery of ex vivo human livers. Hepatology. 2023; 78(3): 820-834.
- Shishido Y, Tracy KM, Wu WK, Cortelli M, Petrovic M, Harris TR, et al. Characterization of porcine immunoglobulin deposition in human livers recovered using xenogeneic cross-circulation. ASAIO. 2024; DOI: 10.1097/MAT.0000000000002311