Inspirex® Liver
Ex vivo organ support system for rehabilitating human donor livers for clinical transplantation
Pioneering donor liver regeneration
Inspirex® Liver rehabilitates human donor livers that are not currently utilized for transplantation to significantly increase the number of livers for patients in need of a life-saving transplant.
Groundbreaking approach to bioengineer human liver grafts for transplant
Inspirex® Liver supports and recovers human donor livers ex vivo by providing durable multi-system physiologic regulation via a xenosupport pig. This robust regenerative setting significantly improves cellular regeneration and functional recovery and radically extends the time for organ evaluation and therapeutic intervention.
Integrated
Normothermic
Systemic
Physiology for
Interventional
Rehabilitation and
Evaluation using
Xenosupport
REFERENCES
- Wu WK, Tumen A, Stokes JW, Ukita R, Hozain A, Pinezich M, O’Neill JD et al. Cross-circulation for extracorporeal liver support in a swine model. ASAIO. 2021; DOI: 10.1097/MAT.0000000000001543.
- Wu WK, Ukita R, Patel YJ, Cortelli M, Trinh VQ, Ziogas IA, et al. Xenogeneic cross-circulation for physiological support and recovery of ex vivo human livers. Hepatology. 2023; 78(3): 820-834.
- Shishido Y, Tracy KM, Wu WK, Cortelli M, Petrovic M, Harris TR, et al. Characterization of porcine immunoglobulin deposition in human livers recovered using xenogeneic cross-circulation. ASAIO. 2024; DOI: 10.1097/MAT.0000000000002311