Inspirex® Lung
Bioengineered human lung grafts for life-saving transplantation
BIOENGINEERING HOPE
More lungs = lives saved
The donor lung shortage is dire: Over 75% of patients on the U.S. transplant waiting list die waiting to receive a lung. INSPIREX® Lung holds potential to save patient lives by significantly increasing the number of human lungs available for transplant.
BREAKTHROUGH BIOTECHNOLOGY
INSPIREX® Lung
A fully functional personalized bioengineered human lung graft ready for transplantation
REFERENCES
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- Guenthart BA, O’Neill JD, Kim J, Queen D, Chicotka S, Fung K, et al. Regeneration of severely damaged lungs using an interventional cross-circulation platform. Nat Commun. 2019;10: 1-16.
- Hozain AE, Tipograf Y, Pinezich MR, Cunningham KM, Donocoff R, Queen D, et al. Multi-day maintenance of extracorporeal lungs using cross-circulation with conscious swine. J Thorac Cardiovasc Surg. 2019; 159: 1640-1653.
- Hozain AE, O’Neill JD, Pinezich MR, Tipograf Y, Donocoff R, Cunningham KM, et al. Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs. Nat Med. 2020; 26: 1102-1113.
- O’Neill JD, Guenthart BA, Hozain AE, Bacchetta M. Xenogeneic support for the recovery of human donor organs. J Thorac Cardiovasc Surg. 2022; 163: 1563-70.
- Wu WK, Guenthart BA, O’Neill JD, Hozain AE, Tipograf Y, Ukita R, et al. Technique for xenogeneic cross-circulation to support human donor lungs ex vivo. J Heart Lung Transplant. 2023; 42(3): 335-344.
- Wu WK, Stier MT, Stokes JW, Ukita R, Patel YJ, Cortelli M, et al. Immune characterization of a xenogeneic human lung cross-circulation support system. Sci Adv. 2023; 9(13): 1-13.
- Pinezich MR, O’Neill JD, Guenthart BA, Kim J, Vila OF, Ma SP, Hozain AE, et al. Theranostic methodology for ex vivo donor lung rehabilitation.