Webinar: Transforming lung fibrosis drug discovery with the IN MATRICO® Human Lung Fibrosis platform
Lung extracellular matrix (ECM) is implicated in the pathogenesis and progression of lung fibrosis. Current preclinical lung fibrosis models do not incorporate lung ECM, and therefore lack the defining part of the fibrotic lung disease environment.
In this webinar, we describe the paradigm shift in drug discovery from ‘in vitro’ to ‘in matrico’, and present our Human Lung Fibrosis platform for disease modeling and compound testing. Leveraging human fibrotic lung ECM and corresponding clinical data, the platform increases the relevance of cell-based assays and enables lung fibrosis modeling with clinical context to accelerate drug development.
Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers
The majority of breast cancer specific deaths in women with estrogen receptor positive (ER+) tumors occur due to metastases that are resistant to therapy. There is a critical need for novel therapeutic approaches to achieve tumor regression and/or maintain therapy responsiveness in metastatic ER+ tumors. The objective of this study was to elucidate the role of metabolic pathways that undermine therapy efficacy in ER+ breast cancers.
Webinar: Redefining cancer research with IN SITE™ Metastasis Kit
In this webinar we present the IN SITE™ Metastasis Kit, which contains tissue-specific bone, liver, and lung ECMs, as an in-vitro tool that enables physiologically-relevant studies of metastasis as well as accelerates drug development efforts.
Application note: IN SITE™ Metastasis Kit to accelerate anticancer drug development
IN SITE™ Metastasis Kit contains bone, liver, and lung ECMs with tissue-specific compositions and mechanics to model colonization of tumor cells in common secondary sites. Recapitulation of site specific microenvironments is key to identify drivers of metastasis and targets for therapeutic intervention.
Poster: TissueSpec® Bone, Liver, and Lung ECM substrates enable disease-relevant in-vitro models of pre-metastatic tissue microenvironments.
Fibrotic Human Lung Extracellular Matrix as a Disease-Specific Substrate for Models of Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis (IPF) is an irreversible and uniformly fatal lung disease marked by destruction and scarring of the lung parenchyma and progressive loss of respiratory function. Unfortunately, predictive models of IPF are not available, underscoring the critical need for physiologically relevant in-vitro substrates that enable quantitative and mechanistic studies of human IPF. Here we report the development and characterization of a human pulmonary fibrosis specific cell culture substrate comprised of intact fibrotic lung extracellular matrix that recapitulates the human IPF disease environment in vitro. Altogether, our results demonstrate the applicability of this fibrosis-specific substrate for 3D in-vitro models of IPF and cell-based assays in early-stage drug discovery.
3D lung tumor model with lung extracellular matrix to predict drug efficacy
Poster: Fibrotic liver extracellular matrix substrates for 3D in-vitro models of human liver fibrosis
Application note: Accelerating anti-fibrotic drug development with human fibrotic liver ECM substrates
Poster: Fibrotic lung extracellular matrix substrates for 3D in-vitro models of human pulmonary fibrosis
Application note: Accelerating anti-fibrotic drug development with human fibrotic lung ECM substrates
Poster: TissueSpec® ECM Hydrogels for predictive 3D models of human cancer
TissueSpec® Intestine ECM Hydrogel Data
TissueSpec® ECM Hydrogel – Preparation for immunostaining
TissueSpec® ECM Hydrogel – Dissociation for cell isolation and analysis
Functional vascularized lung grafts for lung bioengineering. Sci Adv (2017)
Chondrogenic properties of collagen type XI, a component of cartilage extracellular matrix. Biomaterials. (2018)
Constrained cage culture improves engineered cartilage functional properties by enhancing collagen network stability. Tissue Eng Part A. (2017)
Bioengineered models of solid human tumors for cancer research. Methods in Mol Biol. (2016)
Tissue Engineered Autologous Grafts for Facial Bone Reconstruction. Sci Transl Med. (2016)
Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol. (2014)
The regulation of growth and metabolism of kidney stem cells with regional specificity using extracellular matrix derived from kidney. Biomaterials. (2013)
Decellularization of Human and Porcine Lung Tissues for Pulmonary Tissue Engineering. Ann Thorac Surg. (2013)
Engineering bone tissue from human embryonic stem cells. Proc Natl Acad Sci U S A. (2012)
Hybrid Gel Composed of Native Heart Matrix and Collagen Induces Cardiac Differentiation of Human Embryonic Stem Cells without Supplemental Growth Factors. J Cardiovasc Transl Res. (2011)
Composite scaffold provides a cell delivery platform for cardiovascular repair. PNAS (2011)
TissueSpec® ECM Scaffold Product Datasheet
TissueSpec® Lung ECM Hydrogel Product Datasheet
TissueSpec® Liver ECM Hydrogel Product Datasheet
NativeCoat™ ECM Surface Coating Product Datasheet
TissueSpec® ECM Hydrogel instructions for use
Tissue-specific cell culture substrates
Learn more about our tissue-specific cell culture substrates and their application in 3D cell culture.
NativeCoat™ ECM Surface Coating instructions for use
Poster: TissueSpec® Extracellular Matrix Substrates for 3D Cell Culture