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Cell Culture Resources

White Papers

  • 3D lung tumor model with lung extracellular matrix to predict drug efficacy


  • Videos

  • Tissue-specific cell culture substrates

    Learn more about our tissue-specific cell culture substrates and their application in 3D cell culture.


  • Peer-Reviewed Papers

  • Fibrotic Human Lung Extracellular Matrix as a Disease-Specific Substrate for Models of Pulmonary Fibrosis

    Idiopathic Pulmonary Fibrosis (IPF) is an irreversible and uniformly fatal lung disease marked by destruction and scarring of the lung parenchyma and progressive loss of respiratory function. Unfortunately, predictive models of IPF are not available, underscoring the critical need for physiologically relevant in-vitro substrates that enable quantitative and mechanistic studies of human IPF. Here we report the development and characterization of a human pulmonary fibrosis specific cell culture substrate comprised of intact fibrotic lung extracellular matrix that recapitulates the human IPF disease environment in vitro. Altogether, our results demonstrate the applicability of this fibrosis-specific substrate for 3D in-vitro models of IPF and cell-based assays in early-stage drug discovery.


    Chondrogenic properties of collagen type XI, a component of cartilage extracellular matrix. Biomaterials. (2018)


    Bioengineered models of solid human tumors for cancer research. Methods in Mol Biol. (2016)


    Tissue Engineered Autologous Grafts for Facial Bone Reconstruction. Sci Transl Med. (2016)


    Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol. (2014)


    The regulation of growth and metabolism of kidney stem cells with regional specificity using extracellular matrix derived from kidney. Biomaterials. (2013)


    Decellularization of Human and Porcine Lung Tissues for Pulmonary Tissue Engineering. Ann Thorac Surg. (2013)


    Hybrid Gel Composed of Native Heart Matrix and Collagen Induces Cardiac Differentiation of Human Embryonic Stem Cells without Supplemental Growth Factors. J Cardiovasc Transl Res. (2011)


  • Technical Data

  • Poster: TissueSpec® Bone, Liver, and Lung ECM substrates enable disease-relevant in-vitro models of pre-metastatic tissue microenvironments.


    Poster: Fibrotic liver extracellular matrix substrates for 3D in-vitro models of human liver fibrosis


    Application note: Accelerating anti-fibrotic drug development with human fibrotic liver ECM substrates


    Poster: Fibrotic lung extracellular matrix substrates for 3D in-vitro models of human pulmonary fibrosis


    Application note: Accelerating anti-fibrotic drug development with human fibrotic lung ECM substrates


    Poster: TissueSpec® ECM Hydrogels for predictive 3D models of human cancer


    TissueSpec® Intestine ECM Hydrogel Data


    TissueSpec® ECM Scaffold Product Datasheet


    TissueSpec® Lung ECM Hydrogel Product Datasheet


    TissueSpec® Liver ECM Hydrogel Product Datasheet


    NativeCoat™ ECM Surface Coating Product Datasheet


  • Protocols

  • TissueSpec® ECM Hydrogel – Preparation for immunostaining


    TissueSpec® ECM Hydrogel – Dissociation for cell isolation and analysis


    TissueSpec® ECM Hydrogel instructions for use


    NativeCoat™ ECM Surface Coating instructions for use